LEAP2 IMPAIRS THE CAPABILITY OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR TO REGULATE THE DOPAMINE 2 RECEPTOR SIGNALING

LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 receptor (D2R).A key target of GHSR in neurons is voltage-gated calcium channels type 2.2 (CaV2.2).R

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Nanoscale Characteristics and Reactivity of Nascent Soot from n-Heptane/2,5-Dimethylfuran Inverse Diffusion Flames with/without Magnetic Fields

In this study, the differences of Cold nanostructure and oxidation reactivity of the nascent soot formed in n-heptane/2,5-dimethylfuran (DMF) inverse diffusion flames (IDF) with/without influence of magnetic fields were studied, and the effects of DMF-doped and magnetic fields were discussed.Morphology and nanostructures of the soot samples were in

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Thalamic Lesions: A Radiological Review

Background.Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections.In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are Bath Brushes observed only occasionally (often in the presenc

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Sensitivity of Numerical Weather Prediction to the Choice of Variable for Atmospheric Moisture Analysis into the Brazilian Global Model Data Assimilation System

Due to the high spatial and temporal variability of atmospheric water vapor associated with the deficient methodologies used in its quantification and the imperfect physics parameterizations incorporated in the models, there are significant uncertainties in characterizing the moisture field.The process responsible for HAND CREAM incorporating the i

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Small molecule drug discovery targeting the JAK-STAT pathway

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue homeostasis.Dysregulation of this pathway has been implicated in various diseases, including immunodefic

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